![]() ![]() ![]() At minimum, blood cultures and, ideally, sputum cultures should be collected prior to the first antibiotic dose, although antibiotics should not be delayed. However, recent studies have demonstrated that imposing a strict universal time to first antibiotic dose may not be as beneficial in CAP, instead predisposing to excess antibiotic use. Nevertheless, in patients with signs of severe CAP or sepsis, antibiotics should be given within the first hour of hypotension onset to reduce mortality. Quality-improvement efforts aimed at the administration of antibiotics within a certain time period have contributed to increased inappropriate antibiotic use and increased incidence of Clostridium difficile colitis. Rapid initiation of therapy is important for improved outcomes in CAP, although blanket measures to hasten treatment are not without potential negative consequences. ![]()
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